GTAForums users found an interesting clue in updated San Andreas in Grand Theft Auto: The Trilogy — The Definitive Edition. It is a picture of a house on a wall of Lil' Probe'Inn bar. The original game had different images. Upscaled image:
Original texture:
It may not be much, but fans think that it may be a screenshot from GTA 6. At least they think its a picture made on RAGE game engine. We might take a guess and say it isn't a house from GTA 5 or RDR 2. Original:
The Definitive Edition:
Some users think that the house looks like it belong to Florida, and the palm trees is definitely a sign pointing toward Miami. This bold speculations based on a rumor that GTA 6 will bring the action back to Vice City. Until official news from Rockstar Games we advise to take this rumors with a grain of salt.